Is Observation Dead in Follicular Lymphoma? No, But the Apoptosis Pathway Has Been Activated

Is observation dead in follicular lymphoma? No, but the apoptosis pathway has been activated.

Follicular lymphoma (FL), the most common indolent type of non-Hodgkin's lymphoma, presents with a highly variable clinical course and affects the overall survival (OS) of patients. Although observation has been adopted widely by clinicians in the management of patients with FL, the benefits of early treatment must be reviewed in light of the significant progress made in the treatment of sympto...

Is observation dead in follicular lymphoma? Still appropriate.

Given the incurable yet indolent nature of follicular lymphoma (FL) and the lack of a survival benefit seen with the early treatment of patients with a low tumor burden, watchful waiting has been the predominant strategy for treating asymptomatic patients with newly diagnosed FL for more than 2 decades. The success and tolerability of rituximab for the treatment of this disease, however, has le...

Transplantation in follicular lymphoma: not "yes or no" but "whom and when".

Has Every Book of the Bible Been Found Among the Dead Sea Scrolls?

Follicular lymphoma-like B cells of uncertain significance (in situ follicular lymphoma) may infrequently progress, but precedes follicular lymphoma, is associated with other overt lymphomas and mimics follicular lymphoma in flow cytometric studies.

In situ follicular lymphoma, more recently known as follicular lymphoma-like B cells of uncertain/undetermined significance is well accepted. However, the morphological criteria have evolved since it was first described and data are limited and conflicting regarding its clinical implications and whether the extent of involvement predicts an association with overt lymphoma. It is also unknown ho...